CFDB - Cystic Fibrosis DataBase

Welcome in CFDB (Cystic Fibrosis DataBase)!

This is a web-based, free access tool for health care professionals, researchers and students to evaluate in real time what are the current evidences about clinical efficacy of interventions in CF.

You'll find more than 1,500 studies divided in 8 sections, including Cochrane reviews, Cochrane protocols, DARE, HTA and Economic reviews, published RCT, published non-RCT, congress abstracts and ongoing trials.

Objective of CFDB (Cystic Fibrosis DataBase)

CFDB is a database and was ideated to classify clinical studies to get answers to specific questions:

  • which interventions are effective, in which groups of CF patients and for which outcomes?
  • to what extent do the results of the literature allow to make decisions for specific clinical issues? What issues need to be studied further?

This tool may help clinicians, researchers, students to have a faster updated view of clinical research in CF by using queries on the main topics in CF care. It could also be helpful to anyone going to design new studies, as it provides a concise description of what is currently known and what issues, on the contrast, need additional research.

Latest articles

Corrector therapies (with or without potentiators) for people with cystic fibrosis with class II CFTR gene variants (most commonly F508del)

Cochrane Database of Systematic Reviews - Cochrane Review

Details
  • 2020
  • Southern KW

Drug treatments for managing cystic fibrosis‐related diabetes

Cochrane Database of Systematic Reviews - Cochrane Review

Details
  • 2020
  • Onady Gary M

Effect of Expiratory Muscle Training on Peak Cough Flow in Children and Adolescents with Cystic Fibrosis: A Randomized Controlled Trial.

primary studies published RCT

Details
  • 2021
  • Emirza C

Oral cysteamine as an adjunct treatment in cystic fibrosis pulmonary exacerbations: An exploratory randomized clinical trial.

primary studies published RCT

Details
  • 2020
  • Devereux G

A phase 3, randomized, double-blind, parallel-group study to evaluate tezacaftor/ivacaftor in people with cystic fibrosis heterozygous for F508del-CFTR and a gating mutation.

primary studies published RCT

Details
  • 2020
  • McKone EF

CYstic Fibrosis bacterioPHage Study at Yale (CYPHY) - Phase 1|Phase 2 - Not yet recruiting

ongoing trials trial from www.clinicaltrials.gov

Details
  • 2021
  • Yale University

GLP-1 Agonist Therapy in Cystic Fibrosis-Related Glucose Intolerance - Phase 2 - Not yet recruiting

ongoing trials trial from www.clinicaltrials.gov

Details
  • 2021
  • University of Pennsylvania|Children's Hospital of Philadelphia