Study design (if review, criteria of inclusion for studies)
Recruiting. Last update November 2012 - Randomised controlled trial. Parallel
Inclusion criteria: admission to hospital with a pulmonary exacerbation as defined by the Fuchâs Criteria and requiring IV antibiotic treatment; at least 6 years of age (max 18); FEV1 at least 40% predicted. Exclusion criteria: commencement of oral steroids (on admission) or new mucolytic (within 3 months of admission); oxygen requirement or planned surgery during admission; significant haemoptysis during current exacerbation
Inhaled dry powder mannitol 400mg (10 x 40mg capsules) twice daily for 12 days as an adjunctive treatment during hospitalisation for an acute pulmonary exacerbation. Capsules were placed in a special delivery device which pierced the capsule and the contents were inhaled.
Primary Outcome: improvement in clinical status at the end of the treatment period (as assessed using a CF specific clinical score)