Study design (if review, criteria of inclusion for studies)
Randomised controlled trials (RCTs), including crossâover RCTs with a minimum washout period of two weeks. QuasiâRCTs if baseline characteristics of intervention groups are similar (Higgins 2011b)
Individuals of all ages, with a confirmed diagnosis of CF by genotype or sweat chloride testing, with and without PI.
Regimens preâspecifying different administration timings (e.g. before, during or after a meal) in any dosage (dose/kg body weight or dose/g ingested fat or any other strategy) or formulation of PERT in people, of any age, with CF.
Primary outcomes: Fat malabsorption (absolute CFA based on 72âhour stool collection); Nutritional status (change from baseline); weight in kg, % of predicted weight or z score; height in cm, % of predicted height or z score; BMI, % of predicted BMI or z score; Adverse events