Study design (if review, criteria of inclusion for studies)
A limited literature search was conducted of key resources, and titles and abstracts of the retrieved publications were reviewed. Full-text publications were evaluated for final article selection according to predetermined criteria (population, intervention, comparator, outcomes, and study designs).
Participants
CF patients with moderate to severe chronic pulmonary disease
Interventions
Dornase alfa (Pulmozyme) - a purified solution for inhalation of recombinant human deoxyribonuclease (rhDNase)
Outcome measures
clinical effectiveness, cost effectiveness
Main results
The literature search produced 136 citations, with no additional studies identified from the grey literature. Of these, 21 were deemed potentially relevant and 3 met the criteria for inclusion in this review: 1 systematic review, 1 randomized controlled trial, and one economic evaluation.