Study design (if review, criteria of inclusion for studies)
Double-blind, parallel design randomized clinical trial
Participants
Forty CF children
Interventions
Children were assigned to receive either two synbiotic supplements or placebo each day for 6 months.
Outcome measures
The number of pulmonary exacerbations, the frequency of hospitalization and BMI z-score changes over 6 months.
Main results
(Pâ=â0.92), duration and number of hospitalization (Pâ=â0.91 and Pâ=â0.98, respectively) between groups during the intervention. The synbiotic also did not have a significant effect on forced expiratory volume in one second (FEV1, Pâ=â0.22) and BMI z-score (Pâ=â0.77).
Authors' conclusions
The synbiotic had no significant effect on pulmonary and anthropometric outcomes in children with CF. Further studies are necessary to confirm these findings.