CFDB - Cystic Fibrosis DataBase

primary studies published, non RCT

Percutaneous Endoscopic Gastrostomy Tubes May Be Associated With Preservation of Lung Function in Patients With Cystic Fibrosis.

Study design (if review, criteria of inclusion for studies)

Retrospective case-control study


CF patients


CF patients received Percutaneous endoscopic gastrostomy (PEG) (n = 20) and controls did not (n = 40).

Outcome measures

Body mass index (BMI) and forced expiratory volume in 1 second percent predicted (FEV1 )

Main results

After adjusting for mutation class and baseline BMI, BMI percentile increased per month for those with PEG (0.51, 95% confidence interval (CI) = -0.05-1.08, P = .08), but decreased for those without PEG (-0.03, 95% CI = -0.33-0.28, P = .86); however, the difference (0.54; 95% CI = -0.10-1.18, P = .10) was not statistically significant. FEV1 change with time showed a decrease for patients with PEG (-0.04; 95% CI = -0.30-0.22, P = .74) and those without PEG (-.22; 95% CI = -0.45-0.01, P = .06). Although the decrease for those without PEG was higher than those with PEG, the difference between the groups was not statistically significant (0.18; 95% CI = -0.17-0.52, P = .32)

Authors' conclusions

Lung function trajectory showed a trend towards preservation among patients with CF who receive PEG despite lack of significant difference in BMI. There may be a favorable effect of PEG on lung function independent of changes in BMI.

Keywords: non pharmacological intervention - surg; Caloric Intake; non pharmacological intervention - diet; Nutrition Disorders; Malnutrition; Supplementation; Continuous; Enteral Nutrition; Percutaneous Endoscopic Gastrostomy (PEG);