Study design (if review, criteria of inclusion for studies)
Randomised, controlled, cross-over trial.
Fourteen adults with mild to severe CF lung disease (FEV1 31-113% predicted)
Treadmill exercise vs resting breathing and Positive Expiratory Pressure (PEP) therapy
Mucus clearance was measured using the radioaerosol technique and gamma camera imaging.
Treadmill exercise improved whole lung mucus clearance compared to resting breathing (mean difference 3%, 95% CI 2-4), however exercise alone was less effective than PEP therapy (mean difference -7%, 95% CI -6- -8). When comparing treadmill exercise to PEP therapy, there were no significant differences in mucus clearance from the intermediate and peripheral lung regions, but significantly less clearance from the central lung region (likely reflecting the huffing and coughing that was only in PEP therapy).