Study design (if review, criteria of inclusion for studies)
Randomized and quasiârandomized trials of different medical interventions compared to each other or to no intervention or to placebo.
Patiens with CF and rhinosinusitis
medical interventions (e. g. different concentrations of nasal saline irrigations, topical or oral corticosteroids, antibiotics â including nebulized antibiotics, dornase alfa and modulators of the cystic fibrosis transmembrane conductance regulator (CFTR) such as lumacaftor, ivacaftor or tezacaftor) compared to each other or to no intervention or to placebo
improvement of rhinosinusitis, preventing pulmonary exacerbations, improving quality of life
We identified no trials that met the preâdefined inclusion criteria. The most recent searches identified 44 new references, none of which were eligible for inclusion in the current version of this review; 12 studies are listed as excluded and one as ongoing.
We identified no eligible trials assessing the medical interventions in people with cystic fibrosis and chronic rhinosinusitis. Highâquality trials are needed which should assess the efficacy of different treatment options detailed above for managing chronic rhinosinusitis, preventing pulmonary exacerbations and improving quality of life in people with cystic fibrosis.