CFDB - Cystic Fibrosis DataBase

ongoing trials trial from

Study to Evaluate Adverse Events and Change in Disease Activity With Oral Capsules of Galicaftor/Navocaftor/ABBV-119 Combination Therapy in Adult Participants With Cystic Fibrosis - Phase 2 - Not yet recruiting

Study design (if review, criteria of inclusion for studies)

Interventional - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Triple (Participant, Care Provider, Investigator)|Primary Purpose: Treatment


Cystic Fibrosis (CF) - 18 Years and older   (Adult, Older Adult)


Drug: Galicaftor|Drug: Placebo|Drug: Navocaftor|Drug: ABBV-119

Outcome measures

Absolute Change From Baseline in ppFEV1|Absolute Change From Baseline in Sweat Chloride (SwCl)|Absolute Change From Baseline in Forced Vital Capacity [FVC]|Absolute Change From Baseline in Forced Expiratory Flow at Mid-Lung Capacity [FEF25-75]|Relative Changes From Baseline in ppFEV1|Relative Changes From Baseline in FVC|Relative Changes From Baseline in FEF25-75|Absolute Change in CF Questionnaire-Revised (CFQ-R) Respiratory Domain Score From Baseline

Keywords: Adult; Aminophenols; CFTR Modulators; Genetic Predisposition to Disease; pharmacological_intervention; Galicaftor; Navocaftor; ABBV119;