primary studies published RCT Comparative study of the efficacy of 2 respiratory physiotherapy protocols for patients with cystic fibrosis. Year: 1999 Date: 2002 Author: Sànchez Riera H Source Arch Bronconeumol. 1999 Jun;35(6):275-9. Study design (if review, criteria of inclusion for studies) Open cross-over pilot trial, with 2 treatment periods of 3 weeks, with a 3-week washout period. Participants Withdrawals were not discussed within the paper. 14 participants (mean age 13.3 years) with mild to moderate pulmonary involvement. Interventions Treatment consisted of 2 puffs salbutamol via a spacer prior to nebulization of 10 ml HS or 2.5 mg dornase alfa od. Outcome measures Changes from baseline for FEV1 (% predicted). Participants were assessed before and after each period.