Efficacy of pamidronate for osteoporosis in patients with cystic fibrosis following lung transplantation.
Year: 2000
Date: 2004
Author: Aris RM
Source
Am J Respir Crit Care Med. 2000 Sep;162(3 Pt 1):941-6.
Study design (if review, criteria of inclusion for studies)
RCT
Participants
Patients were invited to participate if they had a BMD Z score of -1 or less in the lumbar spine, proximal femur or distal forearm. 15 CF patients and 15 controls
Interventions
calcium 1 g+vitamin D 800 IU or placebo daily, in addition to their regular vitamin D supplements (900 IU/day).
Outcome measures
BMD and bone biochemical markers were measured before and after 1 year of treatment.
Main results
After 12 months, the treatment group showed a reduced rate of bone loss compared with the control group in the lumbar spine (mean difference 1.9% [CI -0.9% to 4.6%]), total hip (mean difference 0.7% [CI -2.2% to 3.5%]) and distal forearm (mean difference 1.7% [CI -2.2% to 5.5%]), but these changes did not reach statistical significance. There was also a trend towards a reduction in bone turnover in the treatment group.
Authors' conclusions
Calcium and vitamin D supplementation reduced the rate of bone turnover and bone loss in adult patients with cystic fibrosis, but these changes did not reach statistical significance. These data suggest that a longer term trial of this simple intervention would be justified.