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primary studies published RCT

Effect of insulinlike growth factor-1 treatment in children with cystic fibrosis.

  • Year: 2001
  • Date: 2005
  • Author: Bucuvalas JC
Source

J Pediatr Gastroenterol Nutr. 2001 Nov;33(5):576-81.

Study design (if review, criteria of inclusion for studies)

Parallel design. Quasi-randomised controlled trial

Participants

< 90% ideal WFH or 5% reduction in ideal WFH over 3 months. CF participants aged >10 years. Age on entry to trial: advice group mean (SD) 16.4 years (6.7); supplement group mean (SD) 19.5 years (11.3). Most recent published report states 15 were enrolled but 2 dropped out. Although 2 out of 7 in the supplement group did not continue taking supplements, they were analysed as ITT

Interventions

Control group received nutritional counselling to increase energy intake by 20% of predicted energy needs by eating high calorie foods. Study period, 3 months. High calorie drink to increase energy intake by 20% of predicted energy needs

Outcome measures

Anthropometric measures* Z scores for weight* and height*, WFH* Pulmonary function* Energy* and nutrient* intake Faecal balance studies

Main results

There was no significant change in energy intake or percent ideal body weight in either group.

Related topics

Psychological interventions for cystic fibrosis patients

Keywords: Adolescent; Adult; Caloric Intake; Child; Counseling; Malnutrition; non pharmacological intervention - diet; non pharmacological intervention - psyco-soc-edu-org; Oral; Supplementation; training; Nutrition Disorders; Psychoeducation;