primary studies published RCT Acute bronchodilator response to a combination of beta-adrenergic and anticholinergic agents in patients with cystic fibrosis. Year: 1992 Date: 1992 Author: Sanchez I Source The Journal of pediatrics YR: 1992 VL: 120 NO: 3 Study design (if review, criteria of inclusion for studies) Dual intervention cross-over trial over 3 days Participants SK score 45 - 90 12 participants (6 males), aged 9 - 22 years Interventions Patients received either single dose nebulised placebo, albuterol 5.0 mg or ipratropium 0.25 mg Outcome measures Changes spirometry (FVC, FEV1, FEF25-75, FEF50, PEFR, FRC, RV, Raw ) measured at baseline and 45 minutes post-treatment Main results Patients with cystic fibrosis had a better acute bronchodilator response to albuterol and ipratropium bromide than to either drug alone. Authors' conclusions Further studies of long-term efficacy and safety seem justified.