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primary studies published RCT

A pilot study of the effect of inhaled buffered reduced glutathione on the clinical status of patients with cystic fibrosis.

  • Year: 2005
  • Date: 2009
  • Author: Bishop C
Source

Chest. 2005 Jan;127(1):308-17.

Study design (if review, criteria of inclusion for studies)

RCT

Participants

30 adult CF subjects with vitamin D insufficiency

Interventions

patients were randomized into one of three treatment arms: D3, D2, or UV light. Subjects randomized to D3 or D2 ingested 50,000 IU of vitamin D weekly, and those randomized to UV exposed their skin to UV light from a lamp five times a week.

Outcome measures

Serum was collected for 25(OH)D and PTH at baseline and at 12 wk

Main results

Treatment with D3 and D2 raised 25(OH)D levels significantly, from a mean of 21.2 +/- 10.18 to 47.1 +/- 20.5 ng/ml (P < 0.001) and 24.4 +/- 10.3 to 32.7+/- 9.7 ng/ml (P = 0.01), with 100% and 60% reaching 25(OH)D levels above 30 ng/ml, respectively. Treatment with UV did not raise 25(OH)D levels significantly; however, only 55% of subjects were adherent with UV therapy.

Authors' conclusions

This study demonstrates that CF subjects are able to achieve or maintain optimal vitamin D status (>30 ng/ml) with two oral regimens of either D3 or D2 treatment, the former being more efficacious. A confounding variable for this observation is the fact that the D3 and D2 capsules contained different carriers, powder-based vs. oil-based, respectively. UV therapy did not alter vitamin D status, possibly due to poor adherence to UV therapy.

Keywords: Adolescent; Adult; Aged; non pharmacological intervention - diet; Nutrition Disorders; prevention; Ultraviolet light; vitamins; Vitamin D; Vitamin D Deficiency; Vitamin deficiencies; Vitamins; pharmacological_intervention;