CFDB - Cystic Fibrosis DataBase

primary studies published RCT

Sequential analysis of surfactant, lung function and inflammation in cystic fibrosis patients.

Study design (if review, criteria of inclusion for studies)

As part of the BEAT trial, this is a longitudinal study

Participants

20 CF patients with normal pulmonary function (median FEV1 94% of predicted)

Interventions

bronchoalveolar lavage fluid at three times over a three year period.

Outcome measures

lung function, surfactant function and endobronchial inflammation

Main results

There was a progressive loss of surfactant function, assessed as minimal surface tension. The decline in surfactant function was negatively correlated to an increase in neutrophilic inflammation and a decrease in lung function, assessed by FEV1, MEF(75/25%VC), and MEF(25%VC). The concentrations of the surfactant specific proteins A, C and D did not change, whereas SP-B increased during this time period.

Authors' conclusions

There may be a link between loss of surfactant function driven by progressive airway inflammation and loss of small airway function in CF patients with limited lung disease.

Keywords: Bacterial Infections; Infection; Pneumonia; Respiratory System Agents; Respiratory Tract Infections; surfactant; Virus; Airway clearance drugs -expectorants- mucolytic- mucociliary-; pharmacological_intervention; Respiratory Tract Diseases;