Study design (if review, criteria of inclusion for studies)
crossover design.
Participants
22 individuals with CF
Interventions
conventional chest physiotherapy (CCPT) and Frequencer therapy
Outcome measures
The sputum weight was the main outcome measure.
Main results
Sputum weight was found to be a reproducible measure of the efficacy of chest physiotherapy in individual patients. The Frequencer induced airway clearance in patients with CF that was equivalent to that of CCPT. Furthermore, treatment of a 4% mucin preparation ex vivo with the Frequencer significantly reduced the viscosity of the mucin solution as determined in a capillary rheometer.
Authors' conclusions
These results indicate the Frequencer is safe and as effective as CCPT in inducing airway clearance in patients with CF.