CHEST YR: 1992 VL: 101 DE: RCT NO: 1

Randomized controlled cross-over trial, single center.

22 people with CF, median age 26 years (14 to 46 years), 17 males and 5 females, matched with 21 people in a control group, median age 29 years (19 to 37 years), 11 males and 10 females. Test of 1 CF participant terminated by physician.

2 consecutive maximal exercise tests, FiO2 0.21 & 0.30.

VO2, duration of exercise, SaO2, PETCO2, tPCO2, VE, VCO2, HR, AT.

CF subjects exercised longer, had a higher maximal Vsimilar2, higher O2 pulse, and less arterial oxygen desaturation when receiving supplemental O2. Control subjects exercised longer when breathing supplemental O2 but had no significant change in maximal Vsimilar2, O2 pulse, or SaO2. Both CF and control subjects had increased end-tidal PCO2 when exercising while breathing supplemental O2.

CF patients with advanced pulmonary disease have increased exercise tolerance and aerobic capacity when exercising while breathing supplemental O2.

Active cycle of breathing technique in cystic fibrosis

Oscillating devices in cystic fibrosis

Positive expiratory pressure in cystic fibrosis