primary studies published RCT Two enteric coated microspheres in cystic fibrosis. Year: 1990 Date: 1990 Author: Williams J Source Arch Dis Child. 1990 Jun;65(6):594-7. Study design (if review, criteria of inclusion for studies) randomised single blind crossover study Participants 39 children with cystic fibrosis and pancreatic insufficiency Interventions Pancrease followed by Creon or vice versa, four weeks' treatment with each preparation Outcome measures coefficient of fat absorption, nitrogen excretion, weight change, and symptom scores Main results Results showed no significant differences between the two preparations in any variable studied. Authors' conclusions there is no significant difference between Pancrease and Creon when compared on a capsule for capsule basis.