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primary studies published RCT

A randomized placebo-controlled study on high-dose oral algal docosahexaenoic acid supplementation in children with cystic fibrosis.

  • Year: 2013
  • Date: 2013
  • Author: Alicandro G
Source

Prostaglandins Leukot Essent Fatty Acids. 2013 Feb;88(2):163-9. doi: 10.1016/j.plefa.2012.10.002. Epub 2012 Dec 21.

Study design (if review, criteria of inclusion for studies)

Randomized controlled trial

Participants

Forty-one CF patients aged from 6 to 12 years

Interventions

High-dose DHA (100 mg/kg/day in the first month and 1g per day thereafter through a 12-month supplementation) or placebo (germ oil).

Outcome measures

Primary outcome was percentage change in plasma AA:DHA ratio. Secondary outcomes were changes in the number of pulmonary exacerbations compared to previous year, lung function, BMI, skinfold thicknesses, and body composition assessed by DXA and in serum concentrations of C-reactive protein, cytokines and vitamin (alpha-tocopherol and retinol).

Main results

Compared to the control group plasma AA:DHA ratio decreased in the intervention group after 6 months (median percentage changes: -73% in the intervention group vs. -10% in the control group, P=0.001). No differences were detected between groups for secondary outcomes. Despite a decrease of the AA/DHA ratio, DHA supplementation for one year did not induce any significant biochemical and clinical improvement in CF patients.

Related topics

Omega-3 fatty acids, zinc and probiotics supplements in cystic fibrosis

Keywords: Child; Anti-Bacterial Agents; Docosahexaenoic Acid -DHA-; non pharmacological intervention - diet; Supplementation; essential fatty acids; omega-3;