Study design (if review, criteria of inclusion for studies)
RCT
Participants
Children with cystic fibrosis (CF) and pancreatic insufficiency (PI)
Interventions
Children were randomized to daily LXS or an isocaloric placebo comparison supplement for 12 months.
Outcome measures
Serum vitamins A (retinol), D (25-hydroxyvitamin D[25D]), E (alpha-tocopherol, alpha-tocopherol:cholesterol ratio), and K (percentage of undercarboxylated osteocalcin [%ucOC] and plasma proteins induced by vitamin K absence factor II [PIVKA II]) were assessed at baseline and 12 months. Dietary intake was determined using 3-day weighed food records and supplemental vitamin intake by a comprehensive questionnaire. Results: A total of 58 subjects (32 boys, age 10.3+2.9 years [mean+standard deviation]) with complete serum vitamin, dietary and supplemental vitamin data were analyzed.
Main results
A total of 58 subjects (32 boys, age 10.3+2.9 years [mean+standard deviation]) with complete serum vitamin, dietary and supplemental vitamin data were analyzed. After adjusting for dietary and supplemental vitamin intake, serum retinol increased 3.0+1.4 mug/dL (coefficient+standard error) (adjusted R 2=0.02, P=0.03) and vitamin K status improved as demonstrated by a decreased percentage of undercarboxylated osteocalcin of-6.0%+1.6% by 12 months (adjusted R2=0.15, P<0.001). These changes occurred in both the LXS and placebo comparison groups. No changes in serum 25D or alpha-tocopherol were detected. Both nutrition interventions increased caloric intake a mean of 83+666 kcal/day by 12 months.
Authors' conclusions
Vitamins A and K status improved, whereas vitamins D and E status was unchanged during 12 months of LXS and isocaloric placebo comparison supplement in children with CF and PI. Copyright 2014 by ESPGHAN and NASPGHAN. Unauthorized reproduction of this article is prohibited.