Study design (if review, criteria of inclusion for studies)
Observational study
Participants
CF patients, aged 10years and over, with normal screening OGTT results (blood glucose at T120min<7.8mmol/l). Two groups were identified according to the max continuous glucose monitoring (CGM) glucose value: Group 1<11mmol/l and Group 2>/=11mmol/l. Among the 38 patients with normal OGTT, 12 (31.6%) were in Group 2.
Interventions
Continuous glucose monitoring (CGM). Two groups were identified according to the max CGM glucose value: Group 1<11mmol/l and Group 2>/=11mmol/l.
Outcome measures
Early glucose tolerance abnormalities; lung function and nutritional status
Main results
Among the 38 patients with normal OGTT, 12 (31.6%) were in Group 2. Compared to Group 1, Group 2 patients exhibited a significant impairment in lung function: FEV1, 68.2+/-25.6% vs. 87.3+/-17%, p=0.01 and FVC, 86.1%+/-19.4% vs. 99.3%+/-13.4%, p=0.021, as well as a higher rate of colonization by P. aeruginosa: 83.3% vs. 44%, p=0.024. Nevertheless, there were no differences in nutritional status (BMI standard deviation score: p=0.079; prealbumin: p=0.364).
Authors' conclusions
CGM reveals early abnormalities of glucose tolerance that remain undiagnosed by OGTT screening and are associated with worse lung function and a higher prevalence of P. aeruginosa colonization in patients with CF.