The effect of probiotics on fecal calprotectin in patients with cystic fibrosis.
Year: 2013
Date: 2013
Author: Fallahi G
Source
Turk J Pediatr. 2013 Sep-Oct;55(5):475-8.
Study design (if review, criteria of inclusion for studies)
RCT
Participants
47 Children with CF
Interventions
In a randomized systematic method, the children were divided into two groups - one group received probiotic powder and another received placebo for four weeks.
Outcome measures
The fecal calprotectin levels were measured by enzyme linked immunosorbent assay.
Main results
Thirty-one of 47 enrolled patients (65.9%) had abnormal fecal calprotectin levels (>50 ?g/g). After the intervention, the fecal calprotectin levels decreased in 29 patients (21 patients in the drug group, and only 8 patients in the placebo group; p<0.001).
Authors' conclusions
This study showed that about two-thirds of patients with CF had intestinal inflammation based on fecal calprotectin levels. Probiotic administration was shown to decrease calprotectin concentrations and subsequently intestinal inflammation in CF patients.