children (5 to 17yrs) with cystic fibrosis (CF) and pancreatic insufficiency (PI).
Interventions
The organized lipid matrix LYM-X-SORB (LXS) vs. placebo dietary supplements with similar calories, total fat and fatty acids. Dietary intake was assessed using 3-day weighed food records.
Outcome measures
Dietary intake was assessed using 3-day weighed food records. Height (HAZ), weight (WAZ), BMI (BMIZ), mid-upper arm muscle (UAMAZ) and fat area (UAFAZ) Z-scores were calculated. Fat mass (FM) and fat-free mass (FFM) were obtained by whole body DXA. REE (kcal/d) was evaluated by indirect calorimetry at baseline, 3 and 12months and %REE calculated using Schofield equations.
Main results
63 children (57% males, age 10.6+/-2.9yr, 43% receiving LXS) completed REE measurements. Caloric intake increased from a median of 2502 [1478, 4909] to 2616 [1660, 4125] kcal/d at 12months. HAZ, WAZ and UAMAZ increased (p<0.05) over 12months. Mean REE was 109+/-8% predicted at baseline and 107+/-9% at 12months (p<0.05). REE (kcal/d) adjusted for FFM and FM decreased over 12months ([mean+/-SE] -31+/-12kcals, p<0.01), significant only in males (-49+/-16kcals, p<0.01).
Authors' conclusions
Over a 12month nutrition intervention with either LXS or placebo, the growth status, muscle stores and REE improved. Sustained increased energy intake improved energy metabolism, growth and nutritional status in school age children with CF, PI and mild lung disease.