Changes in Pulmonary Function and Controlled Ventilation-High Resolution CT of Chest After Antibiotic Therapy in Infants and Young Children with Cystic Fibrosis.
Study design (if review, criteria of inclusion for studies)
retrospective diagnostic survey
Participants
Infants with cystic fibrosis. The sample included 21 infants, mean age 85.2 ± 47.6 weeks.
Interventions
Infant pulmonary function tests (IPFT) and controlled ventilation-high resolution computed tomography (CV-HRCT) of chest done before and after 2 weeks of IV antibiotics over the last 12 years were compared. CV-HRCTs were compared using the modified Brody scoring system.
Outcome measures
CV-HRCTs were compared using the modified Brody scoring system.
Main results
Mean change in weight was 0.4 ± 0.38 kg (p = 0.001). Significant changes in IPFT included mean % predicted FEV(0.5) (+13.5 %, p = 0.043), mean % FEF(25-75) (+30.2 %, p = 0.008), mean %RV/TLC (-11.2 %, p = 0.008), and mean %FRC/TLC (-4.5 %, p = 0.001). Total Brody scores improved from a median of 10 to 5 (p < 0.001) as did mean scores for airway wall thickening (p = 0.050), air trapping (p < 0.001), and parenchymal opacities (p = 0.003).
Authors' conclusions
IPFT and CV-HRCT can be used as objective measures of improvement in lung disease for infants with CF treated with antibiotics.