Study design (if review, criteria of inclusion for studies)
non randomised trial
Participants
Eleven CF patients (mean-age 31.8+/-5.7 months, median age 33 months, 7M/4F) imaged via CT and UTE MRI. Eleven healthy age-matched patients (mean-age 22.5+/-10.2 months, median age 23 months, 5M/6F) imaged via UTE MRI. Thirteen additional patients as a control group (mean-age 24.1+/-11.7 months, median age 24 months, 6M/7F).
Interventions
Eleven CF patients were imaged via CT and UTE MRI. Eleven healthy age-matched patients were imaged via UTE MRI. CT scans of thirteen additional patients obtained for clinical indications not affecting the heart or lungs and interpreted as normal provided a CT control group .
Outcome measures
Studies were scored by two experienced radiologists using a well-validated CF-specific scoring system for CF lung disease.
Main results
Correlations between CT and UTE MRI scores of CF patients were very strong with P-values
Authors' conclusions
UTE MRI detected structural lung disease in very young CF patients and provided imaging data that correlated well with CT. By quantifying early CF lung disease without using ionizing radiation, UTE MRI appears well suited for pediatric patients requiring longitudinal imaging for clinical care or research studies.
Keywords: computed tomography; diagnostic procedures; non pharmacological intervention - diagn;