CFDB - Cystic Fibrosis DataBase

primary studies published RCT

Interval versus constant-load exercise training in adults with Cystic Fibrosis.

Study design (if review, criteria of inclusion for studies)

Randomised controlled trial

Participants

24r adults with CF

Interventions

ercise (IE) compared to constant-load exercise (CLE) training. Patients were randomised to 30-min IE (100 % peak work capacity (WRpeak) for 30-s alternated with 40 % WRpeak for 30-s; n = 12) or 30-min CLE (70 % WRpeak; n = 12) training, 3 times weekly, for 12 weeks.

Outcome measures

Isometric quadriceps muscle strength was assessed using a strain gauge Myometer.

Main results

The magnitude of improvement in quadriceps muscle strength was greater (p = 0.037) in the IE (by 32 ± 13 Nm) compared to the CLE (by 23 ± 12 Nm) groups. Maximum inspiratory and expiratory mouth pressures were significantly improved only in the IE group (by 30 ± 10 cmH(2)O; p = 0.009 and 13 ± 4 cmH(2)O; p = 0.007, respectively). Arterial oxygen saturation during training was higher (p = 0.002) for IE (94 ± 1%) compared to CLE (91 ± 1%), whereas dyspnoea scores were lower (p = 0.001) for IE (3.8 ± 0.7) compared to CLE (5.9 ± 0.8)

Authors' conclusions

IE is superior to CLE in improving peripheral and respiratory muscle strength and preferable to CLE because it is associated with lower exercise-induced arterial oxygen desaturation and breathlessness.

Keywords: Adolescent; Adult; Inhalation OR nebulised; non pharmacological intervention - psyco-soc-edu-org; non pharmacological intervention - devices OR physiotherapy; pharmacological_intervention; training; inspiratory muscle training; exercise; Chest physiotherapy;