Association of Intensity of Anti-Pseudomonal Antibiotic Therapy With Risk of Treatment-Emergent Organisms in Cystic Fibrosis Children with Newly Acquired Pseudomonas Aeruginosa.
Study design (if review, criteria of inclusion for studies)
Randomized controlled study
Participants
Adolescents with cystic fibrosis (CF), clinically stable participants aged between 12 and 18 years
Interventions
Tele-exercise (TE), immersive virtual reality (VR). Patients were included and randomized to a VR-based tele-exercise (VR-TE) or a TE group. Exercises were conducted in groups of 6 participants for 30 min, 3 days/week for 12 weeks in both groups.
Outcome measures
6MWD, FEV(1), hand grip, shoulder flexor and knee extensor muscle strength, Cystic Fibrosis Questionnaire Revised (CFQ-R), physical activity enjoyment scale and system usability scale.
Main results
21 participants completed the study. Baseline pulmonary function tests, 6MWD, muscle strength, and CFQ-R scores were similar between groups. In the VR-TE group, post-training 6MWD was significantly higher than pre-training 6MWD (z = -2.93, p = 0.003). However, no statistical improvement was observed in pulmonary function, muscle strength, or quality of life. Feasibility, enjoyment, adherence, and adverse effects were similar between groups.
Authors' conclusions
Virtual reality and tele-exercise are feasible and motivating methods to facilitate the participation in exercise and improve functional capacity in adolescents with CF. Longer duration of VR-based exercise might be needed to improve muscle strength and quality of life.