Study design (if review, criteria of inclusion for studies)
Retrospective study, data from the national UK Cystic Fibrosis Registry
Eligible individuals included those 12â years and older with a new diagnosis of CFRD. 1613 individuals diagnosed with CFRD between 2008 and 2016.
Change in % predicted forced expiratory volume in 1â s (FEV(1) %) and body mass index z-scores (BMI) over a 5-year follow-up period.
No evidence of an effect of insulin on FEV(1) % over the 5-year study period. Similarly, no overall effect of insulin on BMI; however, there was some evidence for a positive treatment effect in patients with lower baseline BMI.
Using well-established national registry data, authors found no evidence of long-term treatment effects for insulin on FEV(1) % or BMI in people with incident CFRD.