CFDB - Cystic Fibrosis DataBase

primary studies published, non RCT

The long-term effects of insulin use in incident cystic fibrosis-related diabetes: a target trial emulated using longitudinal national registry data.

Study design (if review, criteria of inclusion for studies)

Retrospective study, data from the national UK Cystic Fibrosis Registry


Eligible individuals included those 12 years and older with a new diagnosis of CFRD. 1613 individuals diagnosed with CFRD between 2008 and 2016.



Outcome measures

Change in % predicted forced expiratory volume in 1 s (FEV(1) %) and body mass index z-scores (BMI) over a 5-year follow-up period.

Main results

No evidence of an effect of insulin on FEV(1) % over the 5-year study period. Similarly, no overall effect of insulin on BMI; however, there was some evidence for a positive treatment effect in patients with lower baseline BMI.

Authors' conclusions

Using well-established national registry data, authors found no evidence of long-term treatment effects for insulin on FEV(1) % or BMI in people with incident CFRD.

Keywords: Adult; Diabetes Mellitus; Gastrointestinal Diseases; Hypoglycemic Agents; Insulin; Pancreatic Diseases; pharmacological_intervention; Oral;