HTA - Health Technology Assessment Report Phase 3 Open-Label Clinical Trial of Elexacaftor/Tezacaftor/Ivacaftor in Children Aged 2-5 Years with Cystic Fibrosis and at Least One F508del Allele. Year: 2023 Date: 2013 Author: Goralski JL Source Am J Respir Crit Care Med. 2023 Jul 1;208(1):59-67. doi: 10.1164/rccm.202301-0084OC. Participants CF adults aged 18 years and above Interventions Mannitol as an add-on therapy to best standard of care.