Study design (if review, criteria of inclusion for studies)
Non-randomized clinical trial
Adults with CF -related diabetes (CFRD) resulting from partial-to-complete insulin deficiency. 46 participants
Sensor augmented pump (SAP) therapy, combined with a structured educational program. Of 46 participants who were offered to switch from MDI to SAP therapy, 20 accepted and 26 continued the MDI therapy.
Glycemic control and body composition.
After 24 months changes in HbA1c were: -1.1% (-12.1 mmol/mol) (95% CI: -1.5; -0.8) and -0.1% (-1 mmol/mol) (95% CI: -0.5; 0.3) in the SAP and MDI therapy group, respectively, with a between-group difference of -1.0 (-10 mmol/mol) (-1.5; -0.5). SAP therapy was also associated with a decrease in mean glucose (between group difference: -32 mg/dL; 95% CI: -44; -20) and an increase in TIR (between group difference: 19.3%; 95% CI 13.9; 24.7) and in fat-free mass (between group difference: +5.5 Kg, 95% CI: 3.2; 7.8).
Therapy optimization with SAP led to a significant improvement in glycemic control, which was associated with an increase in fat-free mass.