CFDB - Cystic Fibrosis DataBase

primary studies published, non RCT

Point of care lung ultrasound in preschool children with cystic fibrosis: a case-controlled, prospective, pilot study.

Study design (if review, criteria of inclusion for studies)

Case-control study


Asymptomatic preschool patients affected by CF. A total of 70 enrolled patients (20 patients affected by CF, 50 healthy controls) aged from 3 to 6 years. All included patients were without intercurrent lung problems and without antibiotic therapy in the last 30 days.


Lung ultrasound. For each patient a lung Point of Care Ultrasound (POCUS) of lung was performed.

Outcome measures

Lung ultrasound findings

Main results

B lines < 3 and sub-pleural consolidations < 1 cm were statistically more frequent in CF patients, both in terms of number of affected patients (p 0.02 and p 0.0001 respectively) and frequency (p 0.0181 and p 0.0001 respectively); the prevalence of B lines < 3 in control group was high (47.73%) however the prevalence of sub-pleural consolidations was very low (2.27%). In both groups coalescent B lines affected a greater number of infants and were in higher number of findings than patients aged between 2 and 6 years.

Authors' conclusions

The presence of multiple subpleural pulmonary consolidations < 1 cm in asymptomatic preschool children could be a ultrasound markers of subclinical pulmonary disease such as CF. POCUS of lung is confirmed as a useful tool for the clinician as confirmation of a clinical suspicion, help reduce the use of ionizing radiation.

Keywords: ultrasound; diagnostic procedures; non pharmacological intervention - diagn;