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primary studies published RCT

Coping and learning to Manage Stress with cystic fibrosis (CALM): A multisite telehealth randomized controlled trial to reduce depression and anxiety symptoms in adults with cystic fibrosis.

  • Year: 2024
  • Date:
  • Author: Bathgate CJ
Source

J Cyst Fibros. 2024 Nov 24:S1569-1993(24)01810-1. doi: 10.1016/j.jcf.2024.11.002.

Study design (if review, criteria of inclusion for studies)

Randomized controlled trial

Participants

Adults with cystic fibrosis reporting mild to severe symptoms of depression and/or anxiety

Interventions

"Coping and Learning to Manage Stress with CF" (CALM). Patients were randomized to receive CALM immediately (immediate, n = 66) or after a 13-week delay (waitlist, n = 66).

Outcome measures

Depression and anxiety symptoms. Maintenance of treatment gains from baseline to 3-month follow-up

Main results

Compared to the waitlist group, those that received CALM immediately reported lower depression and anxiety symptoms post-intervention and at 1-month follow-up (ps<0.001). For depression there was a large effect size post-intervention (d = 0.85) and a medium effect size at 1-month follow-up (d = 0.70); anxiety had a medium effect size post-intervention (d = 0.65) and at 1-month follow-up (d = 0.66). The immediate group also reported significantly higher coping self-efficacy, less stress, and increased vitality post-CALM and at 1-month follow-up (ps<0.01). Treatment gains were maintained at 3-month follow-up for all outcomes.

Authors' conclusions

CALM was efficacious for Adults with cystic fibrosis in reducing symptoms of depression, anxiety, and perceived stress while improving coping self-efficacy and vitality with evidence of treatment sustainability. Next steps are dissemination and implementation to CF psychosocial clinicians.

Keywords: Adult; Child; Adolescent; Caregivers; Home; Home Care Services; non pharmacological intervention - psyco-soc-edu-org; telemedicine; Organization;