primary studies published RCT Linoleic acid absorption from lipid supplements in patients with cystic fibrosis with pancreatic insufficiency and in control subjects. Year: 1985 Date: 1992 Author: McKenna MC Source Journal of Pediatric Gastroenterology & Nutrition YR: 1985 VL: 4 DE: CCT NO: 1 Study design (if review, criteria of inclusion for studies) Dual intervention cross-over trial over 3 days Participants SK score 45 - 90 12 participants (6 males), aged 9 - 22 years Interventions Patients received either single dose nebulised placebo, albuterol 5.0 mg or ipratropium 0.25 mg Outcome measures Changes spirometry (FVC, FEV1, FEF25-75, FEF50, PEFR, FRC, RV, Raw ) measured at baseline and 45 minutes post-treatment Main results Patients with cystic fibrosis had a better acute bronchodilator response to albuterol and ipratropium bromide than to either drug alone. Authors' conclusions Further studies of long-term efficacy and safety seem justified.