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primary studies published, non RCT

Advancing Cystic Fibrosis-Related Diabetes Care With Automated Insulin Delivery Systems.

  • Year: 2026
  • Date:
  • Author: Grancini V
Source

Clin Ther. 2026 Jun 16:S0149-2918(26)00157-8. doi: 10.1016/j.clinthera.2026.05.011.

Study design (if review, criteria of inclusion for studies)

Prospective cohort study

Participants

21 adults with Cystic fibrosis-related diabetes (CFRD) were offered AID in place of multiple daily injections (MDI) or sensor-augmented pump (SAP)

Interventions

Patients were offered Automated insulin delivery (AID) in place of multiple daily injections (MDI) or sensor-augmented pump (SAP)

Outcome measures

The Diabetes Treatment Satisfaction Questionnaire (DTSQ) and Audit of Diabetes-Dependent Quality of Life (ADDQoL) were administered at baseline and after 3 months. Primary outcomes were changes in DTSQ and ADDQoL scores; secondary outcomes included continuous glucose monitoring (CGM) metrics.

Main results

After 3 months of AID use, DTSQ scores improved from 22 (IQR: 19-23) to 33 (IQR: 31-35), P < 0.001. ADDQoL scores increased from -2.1 (IQR: -2.7 to -1.2) to -0.9 (IQR: -1.7 to 0.5), P < 0.001. CGM metrics also improved significantly.

Authors' conclusions

These findings provide preliminary evidence suggesting that AID may be a useful tool in the management of CFRD.

Keywords: Diabetes Mellitus; Gastrointestinal Diseases; Pancreatic Diseases; non pharmacological intervention - diagn; diagnostic procedures; Continuous glucose monitoring systems;