Study design (if review, criteria of inclusion for studies)
randomised, controlled double-blind study with crossover
10 boys with CF
pancrealipase (enzyme supplement containing lipase, amylase, and protease) in the form of pH-sensitive microspheres (Pancrease) and in the form of encapsulated enzyme powder (Cotazym)
nitrogen, fat and protein absorption
Patients experienced significantly enhanced nitrogen and fat absorption while receiving either enzyme when compared with placebo. The enteric-coated product promoted significantly improved fat absorption as compared with the conventional enzyme capsule. Both enzyme preparations caused significantly improved protein absorption as compared with placebo, but there was no significant difference between the two products in the degree of effect on azotorrhea.