Study design (if review, criteria of inclusion for studies)
Randomised controlled trial. Parallel design.
Participants
70 adult CF participants. Mean (SD) age: CCPT: 18 years (1.3); HFCC: 22.9 years (2.0). All participants completed.
Interventions
CCPT versus HFCC.
Outcome measures
Sputum weight (wet and dry), VC, FEV1, FEF25-75, SpO2, RV, RV/TLC.
Main results
Significant improvements in clinical status and PFT were observed after 7 and 14 d of treatment, and were similar in the two study groups, leading to patient discharge after similar periods of hospitalization. We conclude that HFCC and CPT are equally safe and effective when used during acute pulmonary exacerbations in CF patients.
Authors' conclusions
HFCC may provide an adequate alternative in management of CF patients in a hospital setting.