primary studies published RCT Correction of vitamin E deficiency with fat-soluble versus water-miscible preparations of vitamin E in patients with cystic fibrosis. Year: 1993 Date: 1993 Author: Nasr SZ Source J Pediatr. 1993 May;122(5 Pt 1):810-2. Study design (if review, criteria of inclusion for studies) randomized trial Participants 27 patients with cystic fibrosis, 17 had levels of alpha-tocopherol more than 2 SD below the mean. Interventions water-miscible form of vitamin E or a fat-soluble form for 6 months. Outcome measures vitamin E serum levels; cost Main results Either form was effective in achieving normal serum levels; the fat-soluble supplement has a significant cost advantage.