Study design (if review, criteria of inclusion for studies)
A limited literature search of key resources was conducted, and titles and abstracts of the retrieved publications were reviewed. Full-text publications were evaluated for final article selection according to predetermined selection criteria (population, intervention, comparator, outcomes, and study designs).
Participants
patients with CF and Pseudomonas aeruginosa
Interventions
Tobramycin (inhaled vs IV tobramycin)
Outcome measures
clinical effectiveness, cost effectiveness
Main results
The literature search produced 527 citations, with an additional 3 studies identified from other sources. Of these, 41 were deemed potentially relevant and 5 met the criteria for inclusion in this review â 3 retrospective studies and 2 evidence-based guidelines. For the treatment of patients with CF there was no evidence found comparing inhaled and IV tobramycin. No decline in kidney function was found with long-term inhaled or IV tobramycin therapy. Adherence rates were low with inhaled tobramycin (increasing hospitalization risk). No evidence was identified for adherence with IV tobramycin therapy.