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primary studies published RCT

Inhaled aztreonam for chronic Burkholderia infection in cystic fibrosis: A placebo-controlled trial.

  • Year: 2013
  • Date: 2013
  • Author: Tullis DE
Source

J Cyst Fibros. 2013 Oct 28. pii: S1569-1993(13)00148-3. doi: 10.1016/j.jcf.2013.08.011.

Study design (if review, criteria of inclusion for studies)

Double-blind, placebo-controlled trial

Participants

Individuals with cystic fibrosis (CF) and chronic Burkholderia spp. infection.

Interventions

24-week of continuous AZLI/placebo treatment

Outcome measures

FEV1% predicted, number of respiratory exacerbations requiring systemic/inhaled antibiotics, or hospitalizations.

Main results

Baseline FEV1% predicted values ranged from 15.8% to 114.6%. No significant treatment differences (AZLI vs. placebo) were observed at week 24 for any endpoints, including FEV1% predicted, number of respiratory exacerbations requiring systemic/inhaled antibiotics, or hospitalizations. Continuous AZLI administration was well tolerated. Burkholderia spp. susceptibility to antibiotics commonly used in CF therapy showed little change.

Authors' conclusions

continuous AZLI treatment did not significantly improve lung function in CF subjects with chronic Burkholderia spp. infection. Non-study antibiotic use may have confounded any potential AZLI effects.

Related topics

Antibiotic treatment of early pseudomonas aeruginosa

Antibiotics for pulmonary exacerbations

Inhaled antibiotics in cystic fibrosis

MRSA eradication in CF

Prophylactic use of oral antistaphylococcal antibiotic

Scheduled antibiotics every 3-4 months / symptom-based treatment

Keywords: Adolescent; Adult; Aged; Anti-Bacterial Agents; Aztreonam; Bacterial Infections; Child; Infection; Inhalation OR nebulised; Respiratory Tract Diseases; Respiratory Tract Infections; Supplementation; Monobactams; pharmacological_intervention; Burkholderia cepacia;