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HTA - Health Technology Assessment Report

Long-Term Safety and Efficacy of Elexacaftor/Tezacaftor/Ivacaftor in Children Aged ⩾6 Years with Cystic Fibrosis and at Least One F508del Allele: A Phase 3, Open-Label Clinical Trial.

  • Year: 2023
  • Date: 2013
  • Author: Wainwright C
Source

Am J Respir Crit Care Med. 2023 Jul 1;208(1):68-78. doi: 10.1164/rccm.202301-0021OC.

Study design (if review, criteria of inclusion for studies)

HTA report

Participants

patients with CF and Pseudomonas aeruginosa

Interventions

Tobramycin inhalation solution

Outcome measures

No studies comparing the differences between both Tobramycin inhalation solution presentations have been found. High quality evidence provided by one single comparative study of the two inhaled formulations did not find significant differences in clinically relevant results. It was found that Tobramycin inhalation powder has advantages in terms of administration and higher satisfaction for the patients although its use is associated to an increased use of other antibiotics and more side effects such as cough. In Argentina, the cost of the treatment implemented in this study is somewhat higher with Tobramycin inhalation powder than with Tobramycin inhalation solution.

Related topics

Antibiotic treatment of early pseudomonas aeruginosa

Antibiotics for pulmonary exacerbations

Inhaled antibiotics in cystic fibrosis

MRSA eradication in CF

Prophylactic use of oral antistaphylococcal antibiotic

Scheduled antibiotics every 3-4 months / symptom-based treatment

Keywords: Anti-Bacterial Agents; Inhalation OR nebulised; pharmacological_intervention; Tobramycin; Bacterial Infections; Respiratory Tract Infections; Respiratory Tract Diseases; Infection; Aminoglycosides;