CFDB - Cystic Fibrosis DataBase

primary studies published RCT

Effects of an early rehabilitation program for adult cystic fibrosis patients during hospitalization: a randomized clinical trial.

Study design (if review, criteria of inclusion for studies)

Randomized controlled trial


34 adults with CF hospitalized for pulmonary exacerbation


An early rehabilitation program. The intervention group underwent an early rehabilitation program for 14 days after admission.

Outcome measures

Lung function, muscle strength, inflammatory markers, and quality of life. All patients underwent spirometry, one-repetition maximum tests (1RM), and the 6-min walk test, and answered the Revised Cystic Fibrosis Questionnaire (CFQ-R) for quality of life and the International Physical Activity Questionnaire. Serum levels of interleukin and tumor necrosis factor alpha (TNF-α) were measured.

Main results

In the intervention group, there were increases in 1RM biceps (P=0.009), triceps (P=0.005), shoulder abductors (P=0.002), shoulder flexors (P=0.004), hamstrings (P<0.001), and quadriceps values (P<0.001). In addition, there were improvements in CFQ-R-emotion (P=0.002), treatment burden (P=0.002), vitality (P=0.011), and physical scores (P=0.026), and a reduction in the Borg resting fatigue score (P=0.037). The interleukins levels did not change after the intervention.

Authors' conclusions

In adult CF patients with pulmonary exacerbation, early hospital rehabilitation had a significant impact on improving resting fatigue, muscle strength, and quality of life.

Keywords: adult; non pharmacological intervention - psyco-soc-edu-org; Home; non pharmacological intervention - devices OR physiotherapy; Organization; training; Infection; Respiratory Tract Diseases; Respiratory Tract Infections; Exacerbation;