primary studies published RCT Ticarcillin compared with carbenicillin in the treatment of exacerbations of bronchopulmonary infection in cystic fibrosis. Year: 1983 Date: 1983 Author: Penketh AR Source Br J Dis Chest. 1983 Apr;77(2):179-84. Study design (if review, criteria of inclusion for studies) randomized trial Participants 16 adults with cystic fibrosis and chronic bronchopulmonary infection with Pseudomonas aeruginosa, admitted to hospital for chemotherapy Interventions carbenicillin or ticarcillin. In addition all patients received gentamicin. Outcome measures respiratory function, Pseudomonas aeruginosa eradication Main results Both antibiotic treatments produced clinical improvement and significant improvement in respiratory function, but there was no difference between them. Pseudomonas aeruginosa was not eradicated from sputum with either treatment regimen. Related topics Antibiotic treatment of early pseudomonas aeruginosa Antibiotics for pulmonary exacerbations Inhaled antibiotics in cystic fibrosis MRSA eradication in CF Prophylactic use of oral antistaphylococcal antibiotic Scheduled antibiotics every 3-4 months / symptom-based treatment