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primary studies published RCT

Treatment of Pseudomonas aeruginosa lung infection in cystic fibrosis with high or conventional doses of ceftazidime.

  • Year: 1998
  • Date: 1998
  • Author: De Boeck K
Source

J Antimicrob Chemother. 1998 Mar;41(3):407-9.

Study design (if review, criteria of inclusion for studies)

RCT

Interventions

ceftazidime 150 mg/kg/day was compared with 320 mg/kg/day.

Outcome measures

Changes in clinical findings, laboratory tests, pulmonary function and chest radiographs were evaluated after 14 days of treatment in hospital.

Main results

Both treatments were associated with a significant improvement, but the higher dose did not offer an additional benefit. An increase in alanine aminotransferase (ALT) occurred after both treatments; with a significantly greater increase after the high-dose therapy (mean increase +/- S.E.M. 8% +/- 2% vs 2% +/- 1 %; P < 0.01). All but one of the ALT values after treatment were within normal limits.

Related topics

Antibiotic treatment of early pseudomonas aeruginosa

Antibiotics for pulmonary exacerbations

Inhaled antibiotics in cystic fibrosis

MRSA eradication in CF

Prophylactic use of oral antistaphylococcal antibiotic

Scheduled antibiotics every 3-4 months / symptom-based treatment

Keywords: Adolescent; Anti-Bacterial Agents; Artificial Ventilation; Bacterial Infections; Ceftazidime; Cephalosporins; Child; Infection; non pharmacological intervention - devices OR physiotherapy; pharmacological_intervention; Pseudomonas aeruginosa; Pseudomonas; Respiratory Tract Diseases; Respiratory Tract Infections; Ventilators; Colonization;