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ongoing trials trial from www.clinicaltrials.gov

Antibiotic Treatment Of Staphylococcus Aureus In Stable People With CF - Phase 3 - Recruiting

  • Year: 2020
  • Date: July 27, 2020
  • Author: University of British Columbia|The Hospital for Sick Children
Source

https://ClinicalTrials.gov/show/NCT04553419

Study design (if review, criteria of inclusion for studies)

Interventional - Allocation: Randomized|Intervention Model: Parallel Assignment|Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)|Primary Purpose: Treatment

Participants

Cystic Fibrosis - 3 Years to 16 Years   (Child)

Interventions

Drug: Cephalexin|Drug: Placebo

Outcome measures

The relative change in LCI2.5 between day 0 and day 14 (relative change = [LCI2.5 at day 14-LCI2.5 at day 0]/LCI2.5 at day 0).|Time to next pulmonary exacerbation|Relative change in percent predicted FEV1 between day 0 and day 14|Absolute change in FEV1 (mL) between day 0 and day 14|Relative change in LCI5 between day 0 and day 14.|Absolute change in LCI2.5 and LCI5 between day 0 and day 14|Absolute change in the CFQ-R(R) between day 0 and day 14.|MSSA airway culture positivity at day 14|Time until next growth of MSSA on clinical microbiology samples|Number of new CF respiratory pathogens (P. aeruginosa etc) from clinical respiratory samples

Related topics

Antibiotic treatment for stenotrophomonas maltophilia in people with cystic fibrosis

Antibiotic treatment of early pseudomonas aeruginosa

Antibiotics for pulmonary exacerbations

Inhaled antibiotics in cystic fibrosis

MRSA eradication in CF

Prophylactic use of oral antistaphylococcal antibiotic

Scheduled antibiotics every 3-4 months / symptom-based treatment

Keywords: Anti-Bacterial Agents; Bacterial Infections; Cephalexin; Child; Infant; Infection; pharmacological_intervention; Pneumonia; Respiratory Tract Diseases; Respiratory Tract Infections; Staphylococcus aureus; Continuous; Cephalosporins;