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primary studies published RCT

Open follow-up study of tobramycin nebuliser solution and colistin in patients with cystic fibrosis.

  • Year: 2006
  • Date: 2006
  • Author: Adeboyeku D
Source

J Cyst Fibros. 2006 Dec;5(4):261-3. Epub 2006 Jun 27.

Study design (if review, criteria of inclusion for studies)

Open randomised cross-over study; extension of a previous study of tobramycin nebuliser solution (TNS) compared with colistin [C] in cystic fibrosis (CF) patients, chronically infected with pseudomonas

Participants

21 patients who had previously been on the 1 cycle study

Interventions

tobramycin nebuliser solution (TNS) compared with colistin [C]. Patients continued for a further 5 months and then crossed over to the alternate treatment

Outcome measures

FEV1 (% pred)

Main results

There was an advantage for TNS over C in FEV(1) % predicted change over time. The C slope was -0.88% per month and the TNS slope 0.35% per month (p=0.0002).

Authors' conclusions

These results suggest advantages of TNS over C in a study with a small number of patients. Larger studies are required.

Related topics

Antibiotic treatment of early pseudomonas aeruginosa

Antibiotics for pulmonary exacerbations

Inhaled antibiotics in cystic fibrosis

MRSA eradication in CF

Prophylactic use of oral antistaphylococcal antibiotic

Scheduled antibiotics every 3-4 months / symptom-based treatment

Keywords: Adolescent; Adult; Anti-Bacterial Agents; Bacterial Infections; Colistin; Infection; Inhalation OR nebulised; nebuliser; non pharmacological intervention - devices OR physiotherapy; pharmacological_intervention; Pseudomonas aeruginosa; Pseudomonas; Respiratory Tract Diseases; Respiratory Tract Infections; Tobramycin; other anti-bacterial agents; Aminoglycosides;