Study design (if review, criteria of inclusion for studies)
Cross-over Study
Participants
20 out-patients with cystic fibrosis and chronic colonization of the respiratory tract with Pseudomonas aeruginosa
Interventions
ten days with OFX, then another ten days with CPX, and vice versa
Outcome measures
Drug concentrations in serum and sputum were assayed.
Main results
The patients' clinical and laboratory parameters were monitored. The side-effects that appeared did not require interrupting treatment. The serum and sputum concentrations were found to be above the minimal inhibitory concentration. Although P. aeruginosa was not eliminated by the therapy, two-thirds of the patients showed improvement during the infection that could be observed clinically and in laboratory measurements.